Gh and igfs important for regulation ...

Although it was recognized that osteoporosis occurs in women, only recently we learned that it is lasix drug for cats also common >> << men, one of the twelve men in the UK have osteoporosis. In many cases, are recognizable causes of osteoporosis,

but a significant portion (about one-third) of these people have idiopathic disease. One of the main problems is that these cases

difficult to treat. An important therapeutic strategy will be to identify the risk of osteoporosis enough men

early, so they can begin preventive measures. In addition, development of new means of treating these people will be >> << important clinical advance. With a focus on osteoporosis in women, however, cellular and molecular basis for male idiopathic osteoporosis

(MIO) are still poorly understood. However, there are some aspects of skeletal regulation which

may be specific to men and that could be the basis for solving these problems. Thus, the importance of estrogen in the

save the adult skeleton in men and women means that cells of bone in men may respond to low levels of hormone. Both estrogen receptor (ER) alpha and beta are expressed in bone in vivo, which may be important for estrogen on

bones of men. In addition, osteoporosis generally appears more and more evidence for defective osteoblast differentiation

is that there is an excess of fat cells to osteoblasts. Low peak bone mass is a powerful risk factor for osteoporosis >> << in later life, bone formation and, consequently, differentiation of osteoblasts, plays a key role in the mechanism, in which it accrues. GH and IGFs are important for regulation of osteoblast differentiation. The evidence now that they are associated with bone mineral density

, especially in men. Genes ERs, GH and IGF-I may be useful candidates with which we can begin

show men the risk of osteoporosis. In addition, the mechanisms by which estrogen, GH and IGF-I regulate the male skeleton

can serve as a basis for developing new means of treating MIO. .